3-Chloro-4-fluorobenzoic acid → 3-chloro-4-fluoro-N-isopropylbenzamide

HRID 1645041

반응식

HRID 1645041 반응식
Cl.[CH:2]([NH2:5])([CH3:4])[CH3:3].[Cl:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[F:16])[C:10](O)=[O:11]>>[Cl:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][C:15]=1[F:16])[C:10]([NH:5][CH:2]([CH3:4])[CH3:3])=[O:11]

참가 물질

3

반응물 2

HCID 5209893-Chloro-4-fluorobenzoic acidHCID 64321372-Propanamine, hydrochloride (1:1)

생성물 1

HCID 583244933-chloro-4-fluoro-N-isopropylbenzamide수율 81%

실험 절차

Using isopropylamine hydrochloride and 3-chloro-4-fluorobenzoic acid in the general procedure for coupling of amines to carboxylic acids, the title compound was obtained (81% yield) as a white solid. ESI-MS: m/z 216 (M+H)+.

출처 및 근거

ORD 기록
ord-8c52fbe1c4164328936fec997e6f98c8
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124606B2

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