참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 반응물 | Dabco | HCID 9237 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Methyl (2E)-2-(2-((6-chloropyrimidin-4-yl)oxy)phenyl)-3-methoxyprop-2-enoate | HCID 11782200 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Azoxystrobin | HCID 3034285 | 95.7% |
반응 단계
Methyl (E)-2-{2-[6-chloropyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (20 g at 97.1% strength; prepared as described in WO 92/08703) was added to MIBK (77 ml) and water (11 ml), followed by 2-cyanophenyl (8.0 g), DABCO (0.07 g) and potassium carbonate (14.1 g). The reaction was heated to 80° C. and monitored for the end of the reaction (complete after 8 hours). The reaction mixture was washed with water at 80° C. Analysis of the MIBK layer revealed a 95.7% yield of methyl (E)-2-{2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl}-3-methoxyacrylate (azoxystrobin).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08124761B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_02 |
|---|
| ORD ID | ord-b0d822d89ec344f3bae619bea0e67e5e |
|---|
| 출처 메모 | uspto-grants-2012_02 |
|---|
