Cesium carbonate → 5-Chloro-3-((5-(4-(3-morpholinopropoxy)phenyl)furan-2-yl)methylene)indolin-2-one

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	4-(3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine	HCID 4649072	—
반응물	3-((5-Bromofuran-2-yl)methylene)-5-chloroindolin-2-one	HCID 66772829	—
용매	1,4-Dioxane--water (1/1)	HCID 21886435	—
생성물	5-Chloro-3-((5-(4-(3-morpholinopropoxy)phenyl)furan-2-yl)methylene)indolin-2-one	HCID 66772214	—

반응 조건

온도	120 °C

반응 단계

To 3-((5-bromofuran-2-yl)methylene)-5-chloroindolin-2-one (50 mg, 0.155 mmol) in dioxane/water (5% water) was added Cs2CO3 (152 mg, 0.466 mmol) and 4-(3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)propyl)morpholine (65 mg, 0.186 mmol). The mixture was degassed with nitrogen for 5 minutes then heated in microwave for 20 minutes at 120° C. The solution was diluted with water and the solid formed was isolated by filtration. The solid was purified by HPLC to yield 5-chloro-3-((5-(4-(3-morpholinopropoxy)phenyl)furan-2-yl)methylene)indolin-2-one. LCMS (M+1=465).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08124649B2
출처 데이터셋	uspto-grants-2012_02
ORD ID	ord-2ddad40b2afa4908807d8b1f904e40cd
출처 메모	uspto-grants-2012_02