m-Chloroperbenzoic acid → 2,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-1H-inden-1-one

HRID 1645379노트

반응식

HRID 1645379 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[C:7](=[CH:15][C:16]1[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=1)[CH2:6]2.ClC1C=CC=C(C(OO)=[O:30])C=1.C(=O)(O)[O-].[Na+]>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[C:7](=[CH:15][C:16]1[CH:21]=[CH:20][N+:19]([O-:30])=[CH:18][CH:17]=1)[CH2:6]2

참가 물질

5

반응물 3

HCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 533951325,6-Dimethoxy-2-(4-pyridyl)methylene-1-indanone

생성물 1

HCID 730716432,3-Dihydro-5,6-dimethoxy-2-[(1-oxido-4-pyridinyl)methylene]-1H-inden-1-one수율 94.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

4-[(5,6-Dimethoxy-1-indanon-2-ylidene)methyl]pyridine (2.5 g) was dissolved in methylene chloride (60 ml) and chilled. m-Chloroperbenzoic acid (2.0 g) was added to reaction mixture and then stirred for 4 hours. Solid obtained was filtered. The wet solid so obtained was stirred with 10% sodium bicarbonate solution. The solid was filtered, washed with acetone and then dried to get the title compound (2.5 g).

후처리

  1. temperaturechilled
  2. customSolid obtained
  3. filtrationwas filtered
  4. customThe wet solid so obtained
  5. filtrationThe solid was filtered
  6. washwashed with acetone
  7. customdried

출처 및 근거

ORD 기록
ord-d39939978e6c49ec94330e8c8a21cb34
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124783B2

반응 노트

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