Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-4,6-dichloropyrimidine → 6-Chloro-N4-[3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-4,6-dichloropyrimidine | HCID 65522 | — |
| 반응물 | 3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline | HCID 17979287 | — |
| 생성물 | 6-Chloro-N4-[3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]pyrimidine-2,4-diamine | HCID 58733366 | — |
반응 단계
Analogously to example 8, the title compound is synthesized from 384 mg (1.47 mmol) of [3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine (from example XXXIV) and 241 mg (1.47 mmol) of 4,6-dichloro-2-pyrimidineamine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737153B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-f4272c53ab6d4617af711badfb970f40 |
| 출처 메모 | uspto-grants-2010_06 |