Acetoxyacetyl chloride → 5-[[2-(Acetyloxy)acetyl]amino]-2,4,6-triiodo-1,3-benzenedicarbonyl dichloride

HRID 1645500

반응식

HRID 1645500 반응식
[NH2:1][C:2]1[C:3]([I:16])=[C:4]([C:13]([Cl:15])=[O:14])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7]([Cl:9])=[O:8].[C:17]([O:20][CH2:21][C:22](Cl)=[O:23])(=[O:19])[CH3:18]>CC(N(C)C)=O>[Cl:9][C:7]([C:6]1[C:10]([I:11])=[C:2]([NH:1][C:22]([CH2:21][O:20][C:17](=[O:19])[CH3:18])=[O:23])[C:3]([I:16])=[C:4]([C:13]([Cl:15])=[O:14])[C:5]=1[I:12])=[O:8]

참가 물질

4

반응물 2

HCID 26297Acetoxyacetyl chlorideHCID 98948585-Amino-2,4,6-triiodoisophthaloyl dichloride

생성물 1

HCID 129431915-[[2-(Acetyloxy)acetyl]amino]-2,4,6-triiodo-1,3-benzenedicarbonyl dichloride

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매2회

실험 절차

5-Amino-2,4,6-triiodo-isophthaloyl dichloride was dissolved in dimethyl acetamide (DAMC) and a solution of acetoxyacetylchloride (2 eq) in DMAc was slowly added with efficient stirring. The reaction mixture was stirred overnight and the following day, the mixture was slowly poured into stirred ice water. The precipitate was filtered off and dried to give the desired material. The structure was confirmed by 1H NMR (CDCl3, 300 MHz): 10.43 (brs, 1H); 4.71 (s, 2H); 2.11 (s, 3H)

후처리

  1. additionthe following day, the mixture was slowly poured
  2. filtrationThe precipitate was filtered off
  3. customdried

출처 및 근거

ORD 기록
ord-b97a9d610b804cbcbdc5a07d1a9c0b68
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124806B2

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