2-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol → HCID 178423505, 화합물

HRID 1645642노트

반응식

HRID 1645642 반응식
[Na].C(C1(CCOC2C=CN=C(C[S:24]([C:26]3[NH:30][C:29]4[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=4[N:27]=3)=O)C=2C)OCC2(OCCO2)CO1)C.[CH3:36]C1(CCO)OCC2(OCCO2)CO1>>[CH3:36][C:33]1[CH:32]=[CH:31][C:29]2[NH:30][C:26]([SH:24])=[N:27][C:28]=2[CH:34]=1

참가 물질

3

반응물 2

HCID 597925642-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanolHCID 667761962-(((4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

생성물 1

HCID 178423505HCID 178423505, 화합물

실험 절차

The same procedure as in the steps (4f) to (4j) of Example 4 was repeated using 2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol obtained in the step (73b) above and 5-methyl-1H-benzimidazole-2-thiol obtained in the step (47a) to obtain the title compound (188 mg, total 12.4% yield) as a white solid.

출처 및 근거

ORD 기록
ord-d94c36d9912c4589bdc5aac5d6cd1744
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124780B2

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