(4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methanol → HCID 178527753, 화합물

HRID 1645646노트

반응식

HRID 1645646 반응식
[Na].CC1C(C[S:23]([C:25]2[NH:29][C:28]3[CH:30]=[CH:31][CH:32]=[CH:33][C:27]=3[N:26]=2)=O)=NC=CC=1OCC1(C)OCC2(OCCO2)CO1.C[C:35]1(C)[O:40]CC(COC2C=CN=C(CO)C=2C)C[O:36]1>>[O:36]1[C:31]2[C:32](=[CH:33][C:27]3[NH:26][C:25]([SH:23])=[N:29][C:28]=3[CH:30]=2)[O:40][CH2:35]1

참가 물질

3

반응물 2

HCID 59792349(4-((2,2-Dimethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methanolHCID 667765502-(((3-Methyl-4-((8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

생성물 1

HCID 178527753HCID 178527753, 화합물

실험 절차

The same procedure as in the steps (5f) to (5h) of Example 5 was repeated using (4-((2,2-dimethyl-1,3-dioxan-5-yl)methoxy)-3-methylpyridin-2-yl)methanol obtained in the step (12b) above and 5H-[1,3]dioxolo[4,5-f]benzimidazole-6-thiol obtained in the step (78c) above to obtain the title compound (347 mg, total 51.9% yield) as a white solid.

출처 및 근거

ORD 기록
ord-beb923bed6fb4ae7809547ae62605b2c
출처 데이터셋
uspto-grants-2012_02
특허 번호
US08124780B2

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