Carbon Dioxide → 2,6-Dichloro-3,5-difluorophenol
반응식
[Cl:1][C:2]1[C:3]([F:14])=[C:4]([C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11])C(O)=O.CN(C)C=O.C(=O)=O.C1(C)C=CC=CC=1>O>[Cl:1][C:2]1[C:3]([F:14])=[CH:4][C:8]([F:13])=[C:9]([Cl:12])[C:10]=1[OH:11]참가 물질
6
실험 절차
50 g of 3,5-dichloro-2,6-difluoro-4-hydroxybenzoic acid and 10 ml of dimethylformamide are mixed, and the mixture is heated. At 105°-130° C., carbon dioxide is evolved, and the mixture is allowed to react at this temperature until the reaction is complete. 200 ml of toluene and then 80 ml of water are subsequently stirred into the mixture, the phases are separated, and the organic phase is dried and subsequently distilled. This gives 34 g of the product having a boiling point of 87°-88° C. and a refractive index of nD20 : 1.5310.
후처리
- temperaturethe mixture is heated
- customAt 105°-130° C.
- customto react at this temperature until the reaction
- customthe phases are separated
- customthe organic phase is dried
- distillationsubsequently distilled
출처 및 근거
- ORD 기록
- ord-9a8ffe5be56c4f909a85e6904799fed1
- 출처 데이터셋
- uspto-grants-1993_01
- 특허 번호
- US05176914
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