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HCID 9956704, 화합물 → HCID 178446367, 화합물

HRID 1645795
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HRID 1645795 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:7]([CH:9]([CH2:15][S:16]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)(=[O:18])=[O:17])[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:8].[NH2:34][C@H:35]([C:43]([OH:45])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:42])[NH2:41]>C(O)C.O>[OH2:2].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][N:6]([CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[C:7]([CH:9]([CH2:15][S:16]([C:19]1[CH:28]=[CH:27][C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=1)(=[O:17])=[O:18])[CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[O:8].[NH2:34][C@H:35]([C:43]([OH:45])=[O:44])[CH2:36][CH2:37][CH2:38][NH:39][C:40](=[NH:41])[NH2:42]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 9956704HCID 9956704, 화합물HCID 178418600HCID 178418600, 화합물

생성물 1

HCID 178446367HCID 178446367, 화합물수율 179.2%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

In a solution of ethanol (19.5 ml) and water (1.2 ml) was dissolved (-)-4-[N-(3-methoxypropyl)-N-pentylcarbamoyl]-5-(2-naphthylsulfonyl)pentanoic acid (7.80 g) and L-arginine (2.84 g) with stirring at 40° C. Insoluble materials (e.g. trash) were collected by filtration and washed with a mixture of ethanol (7 ml) and water (1.3 ml). After combining the filtrate and washing, the mixture was allowed to stand at room temperature, and the precipitated crystals were collected by filtration to obtain 9.80 g of L-arginine (-)-4-[N-(3-methoxypropyl)-N-pentylcarbamoyl]-5-(2-naphthylsulfonyl)pentanoic acid monohydrate.

후처리

  1. filtrationInsoluble materials (e.g. trash) were collected by filtration
  2. washwashed with a mixture of ethanol (7 ml) and water (1.3 ml)
  3. washwashing
  4. customto stand at room temperature
  5. filtrationthe precipitated crystals were collected by filtration

출처 및 근거

ORD 기록
ord-90bfc5007a644f338e3d75f3412f9c95
출처 데이터셋
uspto-grants-1993_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05177069

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