Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile → 4-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]benzonitrile | HCID 240806 | — |
| 반응물 | 4-((1H-Pyrrolo[2,3-B]pyridin-4-YL)oxy)-3-fluoroaniline | HCID 16037965 | — |
| 생성물 | 4-[(2-Amino-6-{[3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amino}-pyrimidin-4-yl)amino]benzonitrile | HCID 17979293 | — |
반응 단계
Analogously to example 25, the title compound is synthesized from 51 mg (0.21 mmol) of [3-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine (from example XIX) and 54 mg (0.22 mmol) of 4-[(2-amino-6-chloropyrimidin-4-yl)amino]benzonitrile (from example XLVII). Purification by preparative HPLC gives the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737153B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-a970582485954ea6b2c103c6a237904d |
| 출처 메모 | uspto-grants-2010_06 |