Piperidine → 3,4-Dihydro-5-[3-(1-piperidinyl)propoxy]-1(2H)-isoquinolinone

HRID 1645916노트

반응식

HRID 1645916 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:7]=1[CH2:8][CH2:9][NH:10][C:11]2=[O:16].[NH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>C(O)C>[N:17]1([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:15]=[CH:14][CH:13]=[C:12]3[C:7]=2[CH2:8][CH2:9][NH:10][C:11]3=[O:16])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 110755405-(3-Chloropropoxy)-3,4-dihydroisoquinolin-1(2H)-one

생성물 1

HCID 183695103,4-Dihydro-5-[3-(1-piperidinyl)propoxy]-1(2H)-isoquinolinone수율 61%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of 0.6 g (2.5 mmol) of 5-(3-chloropropoxy)-3,4-dihydro-1(2H)-isoquinolinone and 0.6 ml (10 mmol) of piperidine in 30 ml of ethanol was refluxed for 40 hours. The mixture was concentrated, dissolved in chloroform and washed with saturated sodium bicarbonate. The organic layer was dried and concentrated. The solid was recrystallized from water to provide 0.44 g (61%) of the desired product; mp 112°-114°.

후처리

  1. temperaturewas refluxed for 40 hours
  2. concentrationThe mixture was concentrated
  3. dissolutiondissolved in chloroform
  4. washwashed with saturated sodium bicarbonate
  5. customThe organic layer was dried
  6. concentrationconcentrated
  7. customThe solid was recrystallized from water

출처 및 근거

ORD 기록
ord-f83c02719f95441f9576a7189413742b
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05177075

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