Water → Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

HRID 1646003노트

반응식

HRID 1646003 반응식
[CH2:1]([N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8])[CH:2]=[CH2:3].O.[NH:14]1[CH2:17][CH2:16][CH:15]1C(O)=O>C1(C)C=CC=CC=1>[N:14]12[CH2:17][CH2:16][CH:15]1[CH2:3][CH:2]1[CH:11]2[CH2:10][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:1]1

참가 물질

5

반응물 3

HCID 962WaterHCID 17288Azetidinecarboxylic AcidHCID 11084330Ethyl allyl(2-oxoethyl)carbamate

생성물 1

HCID 54190177Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

17.1 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl)-carbamate are heated under reflux overnight in a water separator with 10 g (0.1 mol) of azetidine-2-carboxylic acid in 200 ml of toluene. Unreacted amino acid is filtered off with suction, the filtrate is concentrated and the residue is distilled.

후처리

  1. filtrationUnreacted amino acid is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

출처 및 근거

ORD 기록
ord-65e950eb01954877b28171df6385e628
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05177210

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