Water → HCID 19746787, 화합물

HRID 1646498노트

반응식

HRID 1646498 반응식
[CH2:1]([N:3](CC)CC)C.[F:8][C:9]([F:24])([F:23])[CH:10]1[N:14]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[C:12](=O)O1.BrC(=[CH:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=1)C#N.O>C(#N)C>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:13]2[NH:14][C:10]([C:9]([F:24])([F:23])[F:8])=[C:29]([C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)[C:12]=2[C:1]#[N:3])=[CH:16][CH:17]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 110652915(2H)-Oxazolone, 4-(4-chlorophenyl)-2-(trifluoromethyl)-HCID 54334564HCID 54334564, 화합물

생성물 1

HCID 19746787HCID 19746787, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Triethylamine (1.1 g, 0.011 mol) is added dropwise to a mixture of 2-(trifluoromethyl)-4-(4-chlorophenyl)-3-oxazolin-5-one and α-bromo-p-chlorocinnamonitrile in 25 mL of acetonitrile and the mixture is stirred at room temperature for 18 hours. The reaction mixture is poured into 100 mL of water and extracted with two 30 mL portions of ethyl acetate. The combined extracts are washed with 30 mL of water, 30 mL of saturated brine, dried over magnesium sulfate, filtered and the solvent evaporated to leave a brown solid.

후처리

  1. extractionextracted with two 30 mL portions of ethyl acetate
  2. washThe combined extracts are washed with 30 mL of water, 30 mL of saturated brine
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customthe solvent evaporated
  6. customto leave a brown solid

출처 및 근거

ORD 기록
ord-548bfbcba1644b78aa71c0b931cce60f
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05180734

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