Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,3-Propanedithiol → 2-Fluoroadenine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,3-Propanedithiol | HCID 8013 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 6-azido-2-fluoro-7H-purine | HCID 19801267 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 2-Fluoroadenine | HCID 12790 | 92.8% |
반응 단계
Triethylamine (0.40 mL) was added via syringe to a solution of 6-azido-2-fluoropurine (0.256 g) and 1,3-propanedithiol (0.29 mL) in methanol (13.5 mL). After 15 minutes the reaction was complete as judged by TLC and a white precipitate had formed. The precipitate was collected by filtration and washed with two 10 mL portions of methanol and then dried to obtain 0.203 g of 2-fluoroadenine, mp>300° C. This material was identical to an authentic sample by TLC, NMR and IR.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05180824 |
| 출처 데이터셋 | uspto-grants-1993_01 |
| ORD ID | ord-d089e88f144d47ecba88e636713cf25d |
| 출처 메모 | uspto-grants-1993_01 |