1,1'-Carbonyldiimidazole → HCID 10465394, 화합물

HRID 1646751노트

반응식

HRID 1646751 반응식
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH2:11][CH2:12][NH2:13].[C:14](N1C=CN=C1)(N1C=CN=C1)=[O:15]>O1CCCC1>[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]2[C:14](=[O:15])[NH:13][CH2:12][CH2:11][C:3]=12

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 118195262-(3-methyl-1H-indol-2-yl)ethan-1-amine

생성물 1

HCID 10465394HCID 10465394, 화합물수율 40.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
100 °C

실험 절차

To a solution of 2-(3-methylindol-2-yl)ethylamine (1.74 g) in tetrahydrofuran (200 ml) at room temperature was added 1,1'-carbonyldiimidazole (1.6 g) in small portions. After one hour of stirring, the reaction mixture was evaporated in vacuo. The residue was dissolved in toluene and the solution was evaporated in vacuo. The oil obtained was heated at 100° C. for 40 minutes and then cooled. Purification of the residue with silica gel column chromatography (chloroform) gave 3,4-dihydro-5-methylpyrimido[1,6-a]indol-1(2H)-one (0.8 g).

후처리

  1. customthe reaction mixture was evaporated in vacuo
  2. dissolutionThe residue was dissolved in toluene
  3. customthe solution was evaporated in vacuo
  4. customThe oil obtained
  5. temperaturecooled
  6. customPurification of the residue with silica gel column chromatography (chloroform)

출처 및 근거

ORD 기록
ord-9f6f8476120f4adb95651dbc5db63a48
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05180728

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