Pyridine → 2-(3-Methoxy-phenyl)-7-benzofurancarbaldehye

HRID 1646965노트

반응식

HRID 1646965 반응식
[OH:1][C:2]1[C:9](I)=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:19]#[CH:20])[CH:16]=[CH:17][CH:18]=1.N1C=CC=CC=1>C(OCC)(=O)C>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:19]2[O:1][C:2]3[C:3]([CH:4]=[O:5])=[CH:6][CH:7]=[CH:8][C:9]=3[CH:20]=2)[CH:16]=[CH:17][CH:18]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6407531-Ethynyl-3-methoxybenzeneHCID 152099202-Hydroxy-3-iodobenzaldehyde

생성물 1

HCID 149956822-(3-Methoxy-phenyl)-7-benzofurancarbaldehye수율 143%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of 11 g of 2-hydroxy-3-iodo benzaldehyde, 8.6 g of (3-methoxy-phenyl) acetylene and 150 ml of pyridine was refluxed for 45 minutes and then allowed to return to ambient temperature. Ethyl acetate was added, and washing was carried out with an acid solution, followed by drying and concentrating to obtain 16 g of product which was chromatographed on silica (eluant: hexane-isopropyl ether (7-3)) to obtain 9 g of the desired product melting at 55° C. to 60° C.

후처리

  1. temperaturewas refluxed for 45 minutes
  2. customto return to ambient temperature
  3. washwashing
  4. customby drying
  5. concentrationconcentrating

출처 및 근거

ORD 기록
ord-407160e13ca745139678545078a93ff1
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05182295

반응 노트

불러오는 중…