Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Fluorothiophenol → Ethyl 4-fluoro-alpha-[[(2-fluorophenyl)thio]methyl]benzeneacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Fluorothiophenol | HCID 520216 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Ethyl 2-(4-fluorophenyl)acrylate | HCID 19736751 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Ethyl 4-fluoro-alpha-[[(2-fluorophenyl)thio]methyl]benzeneacetate | HCID 19927552 | 82.2% |
반응 단계
The crude product from Step A (3.9 g, 20 mmole) was taken up in 20 ml of ethanol. To this solution, being stirred at room temperature, was added 2-fluorothiophenol (2.5 g, 20 mmole) and 50 mg of solid sodium ethoxide. After stirring for eight hours the ethanol was concentrated and the residue taken up in ether. The ether mixture was washed twice with 15% NaOH solution, dried (MgSO4) and concentrated to a colorless oil (5.3 g, 82% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05182303 |
| 출처 데이터셋 | uspto-grants-1993_01 |
| ORD ID | ord-ae3ef02d26014c06b8231c688f6a2538 |
| 출처 메모 | uspto-grants-1993_01 |