HCID 15670670, 화합물 → HCID 15680278, 화합물
반응식
O[CH2:2][C:3]([NH:6][C:7]([C:9]1[C:10]([C:18]2[C:19]([C:27]([NH:29][C:30]([CH3:34])([CH2:32][OH:33])[CH3:31])=O)=[CH:20][CH:21]=[C:22]3[O:26][CH2:25][O:24][C:23]=23)=[C:11]2[O:17][CH2:16][O:15][C:12]2=[CH:13][CH:14]=1)=[O:8])([CH3:5])[CH3:4]>S(Cl)(Cl)=O>[CH2:25]1[O:24][C:23]2[C:18]([C:10]3[C:11]4[O:17][CH2:16][O:15][C:12]=4[CH:13]=[CH:14][C:9]=3[C:7]3[O:8][CH2:2][C:3]([CH3:5])([CH3:4])[N:6]=3)=[C:19]([C:27]3[O:33][CH2:32][C:30]([CH3:31])([CH3:34])[N:29]=3)[CH:20]=[CH:21][C:22]=2[O:26]1참가 물질
3
실험 절차
N,N'-Bis(3-hydroxy-2-methylpropan-2-yl)-5,6-methylenedioxy-5',6'-methylenedioxy-2,2'-biphenyldicarboxamide (3 g) is added to thionyl chloride (20 ml), and the mixture is stirred at room temperature for 2 hours. The reaction mixture is distilled under reduced pressure to remove thionyl chloride, and the residue is dissolved in ethyl acetate. The solution is washed, dried and distilled to remove the solvent, and the residue is crystallized from diisopropyl ether to give 5,6-methylenedioxy-5',6'-methylenedioxy-2,2'-bis(4,4-dimethyl-4,5-dihydro-2-oxazolyl)biphenyl (2 g) as colorless crystal. M.p. 152°-154° C.
후처리
- distillation