Thionyl Chloride → 4-(Chloromethyl)-[1,3]dioxolo[4,5-c]pyridine

HRID 1647172노트

반응식

HRID 1647172 반응식
O[CH2:2][C:3]1[C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=[CH:5][N:4]=1.S(Cl)([Cl:14])=O.C(=O)([O-])O.[Na+]>C(Cl)Cl>[Cl:14][CH2:2][C:3]1[C:8]2[O:9][CH2:10][O:11][C:7]=2[CH:6]=[CH:5][N:4]=1

참가 물질

5

반응물 3

HCID 24386Thionyl ChlorideHCID 516892Sodium BicarbonateHCID 199264631,3-Dioxolo[4,5-C]pyridine-4-methanol

생성물 1

HCID 199264524-(Chloromethyl)-[1,3]dioxolo[4,5-c]pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-Hydroxymethyl-3,4-methylenedioxypyridine (90 mg, 0.59 mmol) was dissolved in methylene chloride (10 ml) and thionyl chloride (240 mg, 2 mmol) was added. After 10 min at ambient temperature the mixture was hydrolysed with sodium hydrogen carbonate and the phases were separated. The organic phase was dried over sodium sulphate, filtered and concentrated under reduced pressure. Yield: 90 mg (88%) of the title compound (crude).

후처리

  1. customthe phases were separated
  2. dry with materialThe organic phase was dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-36292afafd164e378e21d66a54f93554
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05430042

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