Methyl (E)-4-(4-aminophenyl)-3-butenoate → HCID 178500100, 화합물

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:4][CH:3]=1.CS[C:17]1[NH:18][CH:19]=[CH:20][C:21](=[O:23])[N:22]=1>>[O:23]=[C:21]1[CH:20]=[CH:19][NH:18][C:17]([NH:1][C:2]2[CH:3]=[CH:4][C:5](/[CH:8]=[CH:9]/[CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:6][CH:7]=2)=[N:22]1

참가 물질

반응물 2

HCID 68346334Methyl (E)-4-(4-aminophenyl)-3-butenoate

HCID 178418670HCID 178418670, 화합물

생성물 1

HCID 178500100HCID 178500100, 화합물수율 35.3%

실험 절차

A mixture comprising 3.00 g of methyl (E)-4-(4-aminophenyl)-3-butenoate and 2.34 g of 2-methylthio-1,4-dihydro-4-oxopyrimidine was stirred at 150° to 160° C. for 20 minutes. The reaction mixture was purified by silica gel column chromatography [solvent: dichloromethane/methanol (30:1)] to obtain 1.58 g of the title compound as a light brown powder (yield: 35%).

후처리

customThe reaction mixture was purified by silica gel column chromatography [solvent: dichloromethane/methanol (30:1)]

출처 및 근거

ORD 기록: ord-04fe90182f9f459dbe58f90ddb8469b8
출처 데이터셋: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05430059

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