3-Chlorothiophenol → 3-[[(3-Chlorophenyl)thio]methyl]-2-pyridinecarbonitrile

HRID 1647249노트

반응식

HRID 1647249 반응식
C[O-].[Na+].[Cl:4][C:5]1[CH:6]=[C:7]([SH:11])[CH:8]=[CH:9][CH:10]=1.[C:12]([C:14]1[C:19]([CH2:20]Br)=[CH:18][CH:17]=[CH:16][N:15]=1)#[N:13]>CO>[C:12]([C:14]1[C:19]([CH2:20][S:11][C:7]2[CH:8]=[CH:9][CH:10]=[C:5]([Cl:4])[CH:6]=2)=[CH:18][CH:17]=[CH:16][N:15]=1)#[N:13]

참가 물질

5

반응물 3

HCID 162573-ChlorothiophenolHCID 103754503-(Bromomethyl)pyridine-2-carbonitrileHCID 10942334Sodium Methoxide

생성물 1

HCID 152802283-[[(3-Chlorophenyl)thio]methyl]-2-pyridinecarbonitrile

시약·촉매·용매 1

HCID 887Methanol용매3회

실험 절차

To a stirred, cloudy solution of sodium methoxide (14.7 g, 0.27 mol) in methanol (450 mL), contained in a water bath, add a solution of 3-chlorothiophenol (39.5 g, 0.27 mol) in methanol (95 mL). To the resultant solution add a solution of 2-cyano-3-(bromomethyl)pyridine (48.9 g, 0.25 mol) in methanol (195 mL), and stir the reaction mixture at room temperature for 1 h. Concentrate the reaction mixture under reduced pressure, add 500 mL of ether to the residue, stir, and filter to remove the sodium bromide. Evaporate ether under reduced pressure to obtain the title compound as an amber oil, which may be used without further purification.

후처리

  1. concentrationConcentrate the reaction mixture under reduced pressure
  2. additionadd 500 mL of ether to the residue
  3. stirringstir
  4. filtrationfilter
  5. customto remove the sodium bromide

출처 및 근거

ORD 기록
ord-eccfa7eb6d1249b5856b54ee2c4c26cc
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05430032

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