Trifluoroacetic acid → 2-Amino-N-(1H-benzimidazol-2-ylmethyl)-3-methylpentanamide tris(trifluoroacetate)

HRID 1647346

반응식

HRID 1647346 반응식
CC(OC(=O)[NH:7][CH:8]([C:13]([NH:15][CH2:16][C:17]1[NH:21][C:20]2[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=2[N:18]=1)=[O:14])[CH:9]([CH3:12])[CH2:10][CH3:11])(C)C.[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30]>C(Cl)Cl>[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[F:27][C:28]([F:33])([F:32])[C:29]([OH:31])=[O:30].[NH2:7][CH:8]([CH:9]([CH3:12])[CH2:10][CH3:11])[C:13]([NH:15][CH2:16][C:17]1[NH:18][C:19]2[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=2[N:21]=1)=[O:14]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acid2회HCID 67747066[1-[[(1H-Benzimidazol-2-ylmethyl)amino]carbonyl]-2-methylbutyl]carbamic acid 1,1-dimethylethyl ester

생성물 1

HCID 220685082-Amino-N-(1H-benzimidazol-2-ylmethyl)-3-methylpentanamide tris(trifluoroacetate)

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound is prepared by the procedure of Example 2 using 0.588 g of product from Example 11 in 6 ml of methylene chloride and 1.3 g of trifluoroacetic acid (TFA). The resulting desired intermediate is used as is in the next reaction. The 1HNMR indicates the correct product with associated TFA molecules.

후처리

  1. customas is in the next reaction

출처 및 근거

ORD 기록
ord-c1c35f840070428b904dbe90e280737a
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05430150

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