1-Chloroethyl chloroformate → 1-(Benzothiophen-2-yl)piperazine hydrochloride

HRID 1647404노트

반응식

HRID 1647404 반응식
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[CH:18]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1.[Cl:23]C(OC(Cl)=O)C>ClCCl>[ClH:23].[S:15]1[C:16]2[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=2[CH:18]=[C:14]1[N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

참가 물질

4

반응물 2

HCID 5213051-Chloroethyl chloroformateHCID 217016231-Benzyl-4-(benzothiophen-2-yl)piperazine

생성물 1

HCID 190649731-(Benzothiophen-2-yl)piperazine hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-benzyl-4-(benzothiophen-2-yl)piperazine (1.5 g, 4.9 mmol) in anhydrous dichloromethane (20 ml) at 0° C. under nitrogen was added 1-chloroethylchloroformate (0.68 ml, 6.37 mmol). The mixture was allowed to warm to room temperature, stirred for 1h and concentrated in vacuo. The crude residue was dissolved in methanol (10 ml) and heated to reflux for 30 minutes, left to cool and the title compound collected by filtration (0.6 g), m.p. 240° C. (dec.).

후처리

  1. concentrationconcentrated in vacuo
  2. dissolutionThe crude residue was dissolved in methanol (10 ml)
  3. temperatureheated
  4. temperatureto reflux for 30 minutes
  5. waitleft
  6. temperatureto cool
  7. filtrationthe title compound collected by filtration (0.6 g), m.p. 240° C. (dec.)

출처 및 근거

ORD 기록
ord-34b4b5ed36e84e4e92d41a459c677a66
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05432177

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