Boron tribromide → HCID 10263493, 화합물
반응식
[C:1]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][CH:11]=[CH:10][C:9]=2[O:16]C)(=[O:4])[CH2:2][CH3:3].B(Br)(Br)Br>ClCCl>[C:1]([C:5]1[CH:6]=[N:7][C:8]2[C:13]([C:14]=1[Cl:15])=[CH:12][CH:11]=[CH:10][C:9]=2[OH:16])(=[O:4])[CH2:2][CH3:3]참가 물질
4
실험 절차
3-Propanoyl-4-chloro-8-methoxyquinoline (32 g) was dissolved in dichloromethane (250 ml), cooled to -78°, and boron tribromide (37 ml) added slowly. The solution was allowed to warm slowly to room temperature overnight, then recooled in ice and quenched cautiously with water. The resulting solid was filtered off and washed with water to give crude 3-propanoyl-4-chloro-8-hydroxyquinoline (115 g crude weight), which was used without further purification.
후처리
- temperaturecooled to -78°
- customquenched cautiously with water
- filtrationThe resulting solid was filtered off
- washwashed with water
출처 및 근거
- ORD 기록
- ord-1198ecbcc966492abd66e3aac1c2d6bb
- 출처 데이터셋
- uspto-grants-1995_07
- 특허 번호
- US05432182
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