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Water → N-[3-(hydroxymethyl)phenyl]-N'-[4-(tetradecyloxy)phenyl]urea

HRID 1647589
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HRID 1647589 반응식
[CH2:1]([O:15][C:16]1[CH:21]=[CH:20][C:19]([N:22]=[C:23]=[O:24])=[CH:18][CH:17]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[NH2:25][C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][CH:33]=1)[CH2:29][OH:30].O>O1CCCC1.N1C=CC=CC=1>[OH:30][CH2:29][C:28]1[CH:27]=[C:26]([NH:25][C:23]([NH:22][C:19]2[CH:18]=[CH:17][C:16]([O:15][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])=[CH:21][CH:20]=2)=[O:24])[CH:33]=[CH:32][CH:31]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 962WaterHCID 802933-Aminobenzyl alcoholHCID 11724283p-(Tetradecyloxy)phenyl isocyanate

생성물 1

HCID 10072687N-[3-(hydroxymethyl)phenyl]-N'-[4-(tetradecyloxy)phenyl]urea수율 73.5%

시약·촉매·용매 2

HCID 1049Pyridine용매HCID 8028Tetrahydrofuran
용매
2회

실험 절차

To a 0° C. solution of 13 g of p-(tetradecyloxy)phenyl isocyanate in 70 ml of tetrahydrofuran and 30 ml of pyridine is added over 10 minutes a solution of 7.24 g of 3-aminobenzyl alcohol in 70 ml of tetrahydrofuran with continued stirring for one hour. The mixture is heated until all the solids dissolve then allowed to stand at ambient temperature overnight. The mixture is poured into water and the solid collected. The solid is washed with dilute hydrochloric acid and water then crystallized from ethyl alcohol to give 13.1 g of the desired product as a light pink solid, m.p. 150°-158° C.

후처리

  1. temperatureThe mixture is heated until all the solids
  2. dissolutiondissolve
  3. waitto stand at ambient temperature overnight
  4. customthe solid collected
  5. washThe solid is washed with dilute hydrochloric acid and water
  6. customthen crystallized from ethyl alcohol

출처 및 근거

ORD 기록
ord-40280e7290f34e2abe080a54f1d6c8fe
출처 데이터셋
uspto-grants-1995_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05432189

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