Sodium Methoxide → 4-Methoxy-6-(trifluoromethoxy)pyrimidin-2-amine

HRID 1647681

반응식

HRID 1647681 반응식
[CH3:1][O-:2].[Na+].[NH2:4][C:5]1[N:10]=[C:9](F)[CH:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1>CO>[NH2:4][C:5]1[N:10]=[C:9]([O:2][CH3:1])[CH:8]=[C:7]([O:12][C:13]([F:16])([F:15])[F:14])[N:6]=1

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 150227162-Amino-4-fluoro-6-trifluoromethoxypyrimidine

생성물 1

HCID 150227204-Methoxy-6-(trifluoromethoxy)pyrimidin-2-amine

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

2.7 g (0.015 mol) of 30% strength sodium methylate were added to 2.95 g (0.015 mol) of 2-amino-4-fluoro-6-trifluoromethoxypyrimidine in 50 ml of methanol in the course of 15 minutes at from -5° to 0° C. while stirring. The reaction mixture was stirred for 1 hour at 0° C., warmed up to 25° C. and then evaporated down under reduced pressure, and the residue was stirred with water and extracted twice with methylene chloride. Drying and evaporating down under reduced pressure gave 3.1 g (98% of theory) of the title compound of nD25 =1.4770.

후처리

  1. stirringThe reaction mixture was stirred for 1 hour at 0° C.
  2. customevaporated down under reduced pressure
  3. stirringthe residue was stirred with water
  4. extractionextracted twice with methylene chloride
  5. customDrying
  6. customevaporating down under reduced pressure

출처 및 근거

ORD 기록
ord-abe85b4792ca4e399e5b97ad40549153
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05434124

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