N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine → 5-isobutyl-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1648194노트

반응식

HRID 1648194 반응식
[CH2:1]([C:5]1[C:6](=[O:14])O[C:8](C)(C)[O:9][C:10]=1[CH3:11])[CH:2]([CH3:4])[CH3:3].C=[N:16][C:17]([CH3:26])([C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=1)[CH3:18]>C1(C)C(C)=CC=CC=1>[CH2:1]([C:5]1[C:6](=[O:14])[N:16]([C:17]([CH3:26])([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([Cl:25])[CH:20]=2)[CH3:18])[CH2:8][O:9][C:10]=1[CH3:11])[CH:2]([CH3:3])[CH3:4]

참가 물질

4

반응물 2

HCID 15300847N-methylene-1-methyl-1-(3-chlorophenyl)ethylamineHCID 199189545-isobutyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one

생성물 1

HCID 199189625-isobutyl-6-methyl-3-[1-methyl-1-(3-chlorophenyl)ethyl]-2,3-dihydro-4H-1,3-oxazin-4-one수율 54.3%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

Xylene (1 ml) was added to a mixture of 5-isobutyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.59 g) and N-methylene-1-methyl-1-(3-chlorophenyl)ethylamine (0.55 g), and the resulting mixture was heated at reflux for 60 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.52 g).

후처리

  1. temperaturethe resulting mixture was heated
  2. temperatureat reflux for 60 minutes for reaction
  3. customThe reaction mixture was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-116adac64a8a438e812a14abc08bb7f8
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436224

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