2,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-one → 3-(1,1-dimethyl-2-phenylethyl)6-methyl-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1648197노트

반응식

HRID 1648197 반응식
[C:1]1([C:7]2[C:8](=[O:16])O[C:10](C)(C)[O:11][C:12]=2[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=[N:18][C:19]([CH3:28])([CH3:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:28][C:19]([N:18]1[C:8](=[O:16])[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[C:12]([CH3:13])[O:11][CH2:10]1)([CH3:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

참가 물질

3

반응물 2

HCID 131570242,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-oneHCID 15568651N-methylene-1,1-dimethyl-2-phenylethylamine

생성물 1

HCID 199189533-(1,1-dimethyl-2-phenylethyl)6-methyl-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one수율 77.3%

실험 절차

5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g) and N-methylene-1,1-dimethyl-2-phenylethylamine (0.63 g) were reacted at 140° for 30 minutes. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.74 g).

후처리

  1. customThe reaction mixture was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-6c544c79a5cd4a3e8b40b8803ab0139b
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436224

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