2,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-one → 6-methyl-3-[1-methyl-1-(2naphthyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one

HRID 1648198노트

반응식

HRID 1648198 반응식
[C:1]1([C:7]2[C:8](=[O:16])O[C:10](C)(C)[O:11][C:12]=2[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C=[N:18][C:19]([CH3:31])([C:21]1[CH:30]=[CH:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=1)[CH3:20]>C1(C)C(C)=CC=CC=1>[CH3:13][C:12]1[O:11][CH2:10][N:18]([C:19]([CH3:31])([C:21]2[CH:30]=[CH:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]=2)[CH3:20])[C:8](=[O:16])[C:7]=1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 131570242,2,6-Trimethyl-5-phenyl-2H,4H-1,3-dioxin-4-oneHCID 19918961N-methylene-1-methyl-1-(2-naphthyl)ethylamine

생성물 1

HCID 199189456-methyl-3-[1-methyl-1-(2naphthyl)ethyl]-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one수율 37.6%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A mixture of 5-phenyl-2,2,6-trimethyl-2H,4H-1,3-dioxin-4-one (0.65 g), N-methylene-1-methyl-1-(2-naphthyl)ethylamine (0.60 g) and xylene (3 ml) was heated at reflux for 20 minutes for reaction. The reaction mixture was purified by silica gel chromatography to obtain the captioned compound (0.40 g).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 20 minutes for reaction
  3. customThe reaction mixture was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-f7ad375ac89c4f4a9bdacd01dd5e2fdb
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436224

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