Anthranilamide → HCID 722983, 화합물

HRID 1648213노트

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HRID 1648213 반응식
[C:1]([NH2:10])(=[O:9])[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].C(N(CC)CC)C.Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>O1CCCC1.C(Cl)Cl>[N:22]1[CH:23]=[CH:24][CH:25]=[C:20]([C:19]([NH:4][C:3]2[CH:5]=[CH:6][CH:7]=[CH:8][C:2]=2[C:1]([NH2:10])=[O:9])=[O:26])[CH:21]=1

참가 물질

5

반응물 3

HCID 6942AnthranilamideHCID 8471TriethylamineHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

생성물 1

HCID 722983HCID 722983, 화합물수율 79.1%

시약·촉매·용매 1

HCID 21919333Tetrahydrofurane dichloromethane용매

실험 절차

To a solution of anthranilamide (8.2 g, being on sale) and triethylamine (18.0 g)in 100 mL of tetrahydrofuran/methylene chloride (1:1), was added nicotinoyl chloride hydrochloride (10.8 g). The mixture was allowed to stir at room temperature, under nitrogen atmosphere, for six hours. The solution was then concentrated under reduced pressure. The concentrate was taken up in ethyl acetate and water and the mixture filtered. The solid material was triturated in ether and filtered to give the title compound (11.5 g) as a yellow powder having the following physical data.

후처리

  1. concentrationThe solution was then concentrated under reduced pressure
  2. filtrationwater and the mixture filtered
  3. customThe solid material was triturated in ether
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-43fef8841a4c4572974097215f443c08
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436233

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