Phosgene → 6-Chloroquinazoline-2,4(1H,3H)-dione

HRID 1648216

반응식

HRID 1648216 반응식
[Cl:1][C:2]1[CH:10]=[C:6]([C:7]([NH2:9])=[O:8])[C:5]([NH2:11])=[CH:4][CH:3]=1.[C:12](Cl)(Cl)=[O:13]>O1CCCC1>[Cl:1][C:2]1[CH:10]=[C:6]2[C:5](=[CH:4][CH:3]=1)[NH:11][C:12](=[O:13])[NH:9][C:7]2=[O:8]

참가 물질

4

반응물 2

HCID 6371PhosgeneHCID 788762-Amino-5-chlorobenzamide

생성물 1

HCID 3039986-Chloroquinazoline-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 5-chloroanthranilamide (3.4 g)in tetrahydrofuran (50 mL) was added phosgene (16 mL, 1.93M solution in toluene) via an addition funnel. The reaction mixture was stirred at room temperature for 4 hours and then heated to reflux for another two hours. The reaction mixture was concentrated to a total volume about 10 mL. After cooling, the title compound (3.72 g) having the following physical data, was collected by filtration and dried in vacuum.

후처리

  1. temperatureheated
  2. temperatureto reflux for another two hours
  3. concentrationThe reaction mixture was concentrated to a total volume about 10 mL
  4. temperatureAfter cooling
  5. filtrationwas collected by filtration
  6. customdried in vacuum

출처 및 근거

ORD 기록
ord-6c47f84f579245e3a259b7c032951650
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436233

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