Acetonitrile → 2-Methylquinazoline

HRID 1648248

반응식

[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

참가 물질

반응물 2

HCID 6342Acetonitrile

HCID 760802-Aminobenzophenone

생성물 1

HCID 5889872-Methylquinazoline

실험 절차

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

출처 및 근거

ORD 기록: ord-24ef11ca3139447cbf6d3fe0c9ffbb64
출처 데이터셋: uspto-grants-1995_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05436247

연결된 노트

불러오는 중…