Formic Acid → 5-Methoxy-4-methylbenzimidazole

HRID 1648292노트

반응식

HRID 1648292 반응식
[CH3:1][O:2][C:3]1[C:4]([CH3:11])=[C:5]([NH2:10])[C:6]([NH2:9])=[CH:7][CH:8]=1.[CH:12](O)=O>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]2[NH:9][CH:12]=[N:10][C:5]=2[C:4]=1[CH3:11]

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 5924544-Methoxy-3-methylbenzene-1,2-diamine

생성물 1

HCID 199193885-Methoxy-4-methylbenzimidazole수율 84%

반응 조건

온도
60 °C

실험 절차

A mixture of 4-methoxy-3-methyl-l,2-benzenediamine (2.8 g, 18A mmol) and formic acid (30 mL) was heated at 60° C. for 30 minutes. The formic acid was removed under reduced pressure and the product was partitioned between chloroform and water containing sufficient sodium hydroxide to basify the solution. After evaporation of the solvent the crude product was chromatographed (methanol:chloroform) to give 2.55 g (84%) of 5-methoxy-4-methyl-1H-benzimidazole.

후처리

  1. customThe formic acid was removed under reduced pressure
  2. customthe product was partitioned between chloroform and water containing sufficient sodium hydroxide
  3. customAfter evaporation of the solvent the crude product
  4. customwas chromatographed (methanol:chloroform)

출처 및 근거

ORD 기록
ord-6be311e07a5947c88132b29c86c14593
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436240

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