1-(1H-indol-3-yl)-2-methylpropan-2-amine → [2-(1H-indol-3-yl)-1,1-dimethylethyl][2-(2-methyloxyphenoxy)ethyl]amine hydrochloride

HRID 1648394

반응식

HRID 1648394 반응식
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH3:16])(=O)=O.[Cl:17]C1C=C2C(=CC=1)NC=C2C(C)(C)CN.[NH:32]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:34]([CH2:41][C:42]([NH2:45])([CH3:44])[CH3:43])=[CH:33]1>>[ClH:17].[NH:32]1[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:34]([CH2:41][C:42]([NH:45][CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH3:16])([CH3:43])[CH3:44])=[CH:33]1

참가 물질

4

반응물 3

HCID 93531-(1H-indol-3-yl)-2-methylpropan-2-amineHCID 26712Indole, 5-chloro-3-(2-amino-1,1-dimethylethyl)-HCID 152899932-(2-Methoxyphenoxy)ethyl methanesulfonate

생성물 1

HCID 67809420[2-(1H-indol-3-yl)-1,1-dimethylethyl][2-(2-methyloxyphenoxy)ethyl]amine hydrochloride

실험 절차

Proceeding as in Example 3, but replacing 2-[2-(cyclopropylmethyloxy)phenoxy]ethyl methanesulfonate with 2-(2-methyloxyphenoxy)ethyl methanesulfonate and [1-(5-chloro-1H-indol-3-yl)-1,1-dimethylethyl]amine with [2-(1H-indol-3-yl)-1,1-dimethylethyl]amine, gave [2-(1H-indol-3-yl)-1,1-dimethylethyl][2- (2-methyloxyphenoxy)ethyl]amine hydrochloride, m.p. 156°-158° C.

출처 및 근거

ORD 기록
ord-71ae478e4b684e1f90f4d101d1cf7a1f
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436264

연결된 노트

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