Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethylene Glycol → trans-1-Benzoyl-3-bromo-4-(2-hydroxyethoxy)-pyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethylene Glycol | HCID 174 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 1H-Pyrrole, 1-benzoyl-2,5-dihydro- | HCID 11252283 | — |
| 생성물 | trans-1-Benzoyl-3-bromo-4-(2-hydroxyethoxy)-pyrrolidine | HCID 67598706 | — |
반응 단계
95 g (0.55 mol) of 1-benzoyl-3-pyrroline are dissolved in 380 g of ethylene glycol, and 101 g (0.57 mol) of N-bromosuccinimide are added in 5 g portions over a period of 2 hours at room temperature. The mixture is then stirred overnight at room temperature and poured into water, followed by extraction with methylene chloride, drying over magnesium sulphate and concentration of the solution. The residue (188 g) was chromatographed with ethyl acetate on silica gel.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05436334 |
| 출처 데이터셋 | uspto-grants-1995_07 |
| ORD ID | ord-099060e53aa9435c9af0c2e09017c8a9 |
| 출처 메모 | uspto-grants-1995_07 |