2,3-Bis(mercaptoisobutryl) propionic acid → 2,3-Bis(mercaptoisobutryl)propanol

HRID 1648504노트

반응식

HRID 1648504 반응식
[SH:1][C:2]([CH3:17])([CH3:16])[C:3]([CH:5]([CH2:9][C:10](=[O:15])[C:11]([SH:14])([CH3:13])[CH3:12])[C:6](O)=[O:7])=[O:4]>O1CCCC1.B.C1COCC1>[SH:1][C:2]([CH3:17])([CH3:16])[C:3]([CH:5]([CH2:9][C:10](=[O:15])[C:11]([SH:14])([CH3:13])[CH3:12])[CH2:6][OH:7])=[O:4]

참가 물질

4

반응물 1

HCID 867445382,3-Bis(mercaptoisobutryl) propionic acid

생성물 1

HCID 867445372,3-Bis(mercaptoisobutryl)propanol

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 2723981Borane;tetrahydrofuran용매

실험 절차

To an ice-cold solution of 2,3-bis(mercaptoisobutryl) propionic acid 9 (Scheme 1) (1 mmol) in 10 mL of anhydrous tetrahydrofuran, 1.5 mL of 1M BH3.THF is added over a period of 5 minutes (min.). The solution is stirred for another 10 min. and evaporated to dryness. Ten ml of water is added to the residue and the mixture is extracted with ethyl acetate. The organic layer is washed with water, dried and evaporated in vacuo to give the product 21, which is purified by flash column chromatography.

후처리

  1. customevaporated to dryness
  2. additionTen ml of water is added to the residue
  3. extractionthe mixture is extracted with ethyl acetate
  4. washThe organic layer is washed with water
  5. customdried
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-fb40702f5097419ba1326776339c536e
출처 데이터셋
uspto-grants-1995_07
특허 번호
US05436352

반응 노트

불러오는 중…