Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Ethynyl-4-methoxybenzene → 1-[4-(4-Methoxyphenylethynyl)phenoxy]-2-diethylaminoethane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Ethynyl-4-methoxybenzene | HCID 251020 | — |
| 반응물 | 2-(4-bromophenoxy)-N,N-diethylethanamine | HCID 423953 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-[4-(4-Methoxyphenylethynyl)phenoxy]-2-diethylaminoethane | HCID 20481562 | 80% |
반응 단계
To a solution of 15 g (0.06 mole) of 1-(4-bromophenoxy)-2-diethylaminoethane and 8.2 g (0.062 mole) of 4-methoxyphenylacetylene in 150 ml of triethylamine are added, under nitrogen, 420 mg of the palladium complex PdCl2 [P(C6H5)2 ]2 and 228 mg of copper(I) iodide. The reaction mixture is subsequently refluxed for 24 hours, then concentrated, and the residue is taken up in water. After extraction with 200 ml of ether, the combined ethereal phases are washed 3 times with water, dried and evaporated to dryness. The crude product is chromatographed on silica gel, affording 15.5 g (80%) of 1-[4-(4-methoxyphenylethynyl)phenoxy]-2-diethylaminoethane with a melting point of 59°-60° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04412856 |
| 출처 데이터셋 | uspto-grants-1983_11 |
| ORD ID | ord-2a39689c8236429aa40f690711c5e80e |
| 출처 메모 | uspto-grants-1983_11 |