3-Pyridinecarbonyl chloride, hydrochloride (1:1) → 4-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

HRID 1648747노트

반응식

HRID 1648747 반응식
[C:1]([C:5]1[CH:10]=[C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:8]=[CH:7][C:6]=1[OH:17])([CH3:4])([CH3:3])[CH3:2].Cl.[C:19](Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1>N1C=CC=CC=1>[C:19]([O:17][C:6]1[CH:7]=[CH:8][C:9]([CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:10][C:5]=1[C:1]([CH3:4])([CH3:2])[CH3:3])(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[N:22][CH:21]=1

참가 물질

4

반응물 2

HCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 97946452-t-butyl-4-cyclohexylphenol

생성물 1

HCID 1985864-Cyclohexyl-2-(1,1-dimethylethyl)phenyl 3-pyridinecarboxylate

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
35 °C

실험 절차

12 g (52 mmol) of 2-t-butyl-4-cyclohexylphenol and 10 g (56 mmol) of nicotinic acid chloride hydrochloride was mixed with 150 ml of dry pyridine and stirred for 48 hours at 35° C. After cooling precipitated pyridine hydrochloride was sucked off and the filtrate mixed with 75 ml of water. The precipitated raw product was freed from pyridine by washing with water and recrystallized from alcohol.

후처리

  1. temperatureAfter cooling
  2. customprecipitated pyridine hydrochloride
  3. additionthe filtrate mixed with 75 ml of water
  4. customThe precipitated raw product
  5. washby washing with water
  6. customrecrystallized from alcohol

출처 및 근거

ORD 기록
ord-b97418d47680424a80a3cfb888d6e53d
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04412998

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