Imidazole → HCID 13269112, 화합물

HRID 1648750노트

반응식

HRID 1648750 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH:8]1[O:17][CH:9]1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16].[NH:18]1[CH:22]=[CH:21][N:20]=[CH:19]1>O>[OH:17][CH:8]([C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Cl:1])[CH:9]([N:18]1[CH:22]=[CH:21][N:20]=[CH:19]1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[Cl:16]

참가 물질

4

반응물 2

HCID 795ImidazoleHCID 3009192,3-Bis(2-chlorophenyl)oxirane

생성물 1

HCID 13269112HCID 13269112, 화합물수율 86.8%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 11 g (0.04 m) of 2,2'-dichloro-α,α'-epoxybibenzyl and 15 g (0.22 m) of imidazole is heated at 160° for 11/2 hours. The reaction is cooled, diluted with water, and extracted with ether. The combined ether extracts are washed with water, then saturated sodium chloride solution, and dried over MgSO4. Solvent is evaporated to give 12 g of a gummy solid, mp 62°-68°.

후처리

  1. temperatureis heated at 160° for 11/2 hours
  2. temperatureThe reaction is cooled
  3. extractionextracted with ether
  4. washThe combined ether extracts are washed with water
  5. dry with materialsaturated sodium chloride solution, and dried over MgSO4
  6. customSolvent is evaporated

출처 및 근거

ORD 기록
ord-fc1e1e8f49d54d999cc857014546529a
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04413003

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