Imidazole → 1-[2-Hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole

HRID 1648752노트

반응식

HRID 1648752 반응식
Cl[CH2:2][C:3]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[Cl:16])([OH:8])[CH2:4][CH2:5][CH2:6][CH3:7].[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.O>CN(C)C=O>[OH:8][C:3]([C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1[Cl:16])([CH2:4][CH2:5][CH2:6][CH3:7])[CH2:2][N:17]1[CH:21]=[CH:20][N:19]=[CH:18]1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 962WaterHCID 132368981-Chloro-2-(2,4-dichlorophenyl)hexan-2-ol

생성물 1

HCID 130588771-[2-Hydroxy-2-(2,4-dichlorophenyl)hexyl]imidazole수율 94.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 40 g (0.14 m) of 1-chloro-2-(2,4-dichlorophenyl)hexan-2-ol and 38.6 g (0.57 m) of imidazole in 10 ml of dimethyl formamide is heated at 160° for one hour. The reaction mixture is cooled, poured into 300 ml of water and extracted with ether. The combined ether extracts are washed with water, then saturated sodium chloride solution and dried over MgSO4. Solvent is evaporated to give 42 g of a gummy brown solid, mp 78°-80°.

후처리

  1. temperatureis heated at 160° for one hour
  2. temperatureThe reaction mixture is cooled
  3. extractionextracted with ether
  4. washThe combined ether extracts are washed with water
  5. dry with materialsaturated sodium chloride solution and dried over MgSO4
  6. customSolvent is evaporated

출처 및 근거

ORD 기록
ord-399e614dc4124a21952f9b8e4eb1c762
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04413003

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