Ethyl isocyanate → N-(Ethylcarbamoyl)-N-[(ethylcarbamoyl)oxy]propanamide

HRID 1648765노트

반응식

HRID 1648765 반응식
[C:1]([NH:5][OH:6])(=[O:4])[CH2:2][CH3:3].[CH2:7]([N:9]=[C:10]=[O:11])[CH3:8]>C(N(CC)CC)C.C(Cl)Cl>[CH2:7]([NH:9][C:10]([N:5]([O:6][C:10]([NH:9][CH2:7][CH3:8])=[O:11])[C:1](=[O:4])[CH2:2][CH3:3])=[O:11])[CH3:8]

참가 물질

5

반응물 2

HCID 8022Ethyl isocyanateHCID 75743N-Hydroxypropanamide

생성물 1

HCID 13228807N-(Ethylcarbamoyl)-N-[(ethylcarbamoyl)oxy]propanamide

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 6344Dichloromethane용매

실험 절차

Propiohydroxamic acid (4.5 grams), ethyl isocyanate (8.0 grams), and a few drops of triethylamine were added to 100 ml of methylene chloride and allowed to stand at room temperature for about 12 hours. The solvent was then removed under vacuum leaving a residue which was recrystallized from a solution of methylene chloride and hexane leaving the desired, N-((ethylamino)carbonyl)-N-(((ethylamino)carbonyl)oxy)propionamide as white crystals, m.p. 104°-106° C.

후처리

  1. customThe solvent was then removed under vacuum
  2. customleaving a residue which
  3. customwas recrystallized from a solution of methylene chloride and hexane leaving the

출처 및 근거

ORD 기록
ord-927f6c10ae484f9babd8e38cfc30aa76
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04413009

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