8-Methoxy-6-nitro-3,4-dihydroquinolin-2(1H)-one → 6-Amino-8-methoxy-3,4-dihydrocarbostyril
반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([O:14][CH3:15])[CH:13]=1)[NH:10][C:9](=[O:16])[CH2:8][CH2:7]2)([O-])=O.[H][H]>C(O)C.[C].[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([O:14][CH3:15])[CH:13]=1)[NH:10][C:9](=[O:16])[CH2:8][CH2:7]2참가 물질
5
실험 절차
6-Nitro-8-methoxy-3,4-dihydrocarbostyril (2 g) and 5% palladium-carbon (0.2 g) were added in ethanol (50 ml) and catalytic reduction was conducted at a hydrogen gas pressure of 3 kg/cm2 for 1 hour. Then, the reaction mixture was filtered and the filtrate was concentrated. The residue was recrystallized from benzene to give 1.7 g of 6-amino-8-methoxy-3,4-dihydrocarbostyril.
후처리
- filtrationThen, the reaction mixture was filtered
- concentrationthe filtrate was concentrated
- customThe residue was recrystallized from benzene
출처 및 근거
- ORD 기록
- ord-3ea3c1d9c82b40eba481b1683f89d792
- 출처 데이터셋
- uspto-grants-1983_11
- 특허 번호
- US04414390
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