Diethyl (ethoxymethylene)malonate → HCID 86739115, 화합물

반응식

[NH2:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]([CH2:9][CH3:10])[CH3:8])[N:6]=1.C(O[CH:14]=[C:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:16]([O:18][CH2:19][CH3:20])=[O:17])C>>[C:21]([C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][NH:1][C:2]1[S:3][CH:4]=[C:5]([CH:7]([CH2:9][CH3:10])[CH3:8])[N:6]=1)([O:23][CH2:24][CH3:25])=[O:22]

참가 물질

반응물 2

HCID 6871Diethyl (ethoxymethylene)malonate

HCID 132533564-(1-Methylpropyl)-2-thiazolamine

생성물 1

HCID 86739115HCID 86739115, 화합물수율 99.9%

실험 절차

2-Amino-4-(2-butyl)thiazole (8.44 g., 54 mmoles) and diethyl ethoxymethylenemalonate (11.7 g., 54 mmoles) were combined and heated on a steam bath for 1 hour and cooled to yield 2-(2,2-dicarbethoxyethenylamino)-4-(2-butyl)thiazole (17.6 g., Rf 0.75 on silica gel thin layer chromatography with chloroform/1% ethanol as eluant).

후처리

temperatureheated on a steam bath for 1 hour
temperaturecooled

출처 및 근거

ORD 기록: ord-e64f1ca01e9f411991865eb899d65422
출처 데이터셋: uspto-grants-1983_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04414388

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