Thionyl Chloride → 7,8-Dihydroxychromone-3-carbonyl chloride

HRID 1649126노트

반응식

HRID 1649126 반응식
[OH:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([C:6](=[O:16])[C:7]([C:13](O)=[O:14])=[CH:8][O:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:19])=O>>[OH:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([C:6](=[O:16])[C:7]([C:13]([Cl:19])=[O:14])=[CH:8][O:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24386Thionyl Chloride2회HCID 127658447,8-Dihydroxychromone-3-carboxylic acid

생성물 1

HCID 130830427,8-Dihydroxychromone-3-carbonyl chloride

실험 절차

7,8-Dihydroxychromone-3-carboxylic acid (6.6 g) together with thionyl chloride (25 ml) were refluxed for one hour. Certain unreacted thionyl chloride remained in the reaction mixture was distilled off, and after addition of benzene to the residue, the mixture was again subjected to distillation. To the residue was added n-hexane to cause trituration of the residue. The solid matter thus formed was recovered by filtration. There was thus obtained the desired product (7.2 g).

후처리

  1. distillationwas distilled off
  2. additionafter addition of benzene to the residue
  3. distillationthe mixture was again subjected to distillation
  4. additionTo the residue was added n-hexane
  5. customThe solid matter thus formed
  6. filtrationwas recovered by filtration

출처 및 근거

ORD 기록
ord-817e109aab524326bc5990cc5a6b7c94
출처 데이터셋
uspto-grants-1983_11
특허 번호
US04415567

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