Phosphorus pentachloride → 3-Chloro-1-(4-chlorophenyl)-1-(3-pyridyl)-1-propene
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)(O)[CH:9]=[CH2:10])=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:19]>C(Cl)Cl>[Cl:19][CH2:10][CH:9]=[C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1참가 물질
4
실험 절차
A solution of crude 1-(4-chlorophenyl)-1-(3-pyridyl)-2-propen-1-ol (40 mmol) in 100 ml methylene chloride was added dropwise to a suspension of phosphorus pentachloride (12.4 g, 60 mmol) at 10° C. After stirring for 1 h at room temperature the solution was washed with 50 ml water at 0° to 10° C. The solution of the crude title compound was used in the following aminations, i.e. Example 2 and 3.
후처리
- washwas washed with 50 ml water at 0° to 10° C
출처 및 근거
- ORD 기록
- ord-b3c17d07c81f46daa5f2d8b124e72eb4
- 출처 데이터셋
- uspto-grants-1983_11
- 특허 번호
- US04418065
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