Triethylamine → HCID 14280741, 화합물

HRID 1649777노트

반응식

HRID 1649777 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11](O)[CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15].C(N(CC)CC)C.CS([Cl:30])(=O)=O.[F:31][C:32]1[CH:45]=[CH:44][C:35]([C:36]([CH:38]2[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]2)=[O:37])=[CH:34][CH:33]=1>ClCCl.O1CCOCC1>[ClH:30].[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH:11]([N:41]1[CH2:42][CH2:43][CH:38]([C:36](=[O:37])[C:35]2[CH:34]=[CH:33][C:32]([F:31])=[CH:45][CH:44]=2)[CH2:39][CH2:40]1)[CH2:12][N:13]([CH2:16][CH3:17])[CH2:14][CH3:15]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 407267HCID 407267, 화합물HCID 27244404-(4-Fluorobenzoyl)piperidine

생성물 1

HCID 14280741HCID 14280741, 화합물

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

1.4 g of 1-(2-naphthyl)-2-diethylaminoethanol was dissolved in 20 ml of dichloromethane. 2.4 ml of triethylamine and 0.9 ml of methanesulfonyl chloride were added to the solution under cooling with ice and the mixture was stirred at room temperature for 4.5 h. A solution of 1.2 g of 4-(p-fluorobenzoyl)piperidine in 25 ml of dioxane was added to the reaction mixture and the obtained mixture was refluxed for 2 h. After completion of the reaction, the product was purified according to silica gel column chromatography and then converted into its hydrochloride.

후처리

  1. temperatureunder cooling with ice
  2. temperaturethe obtained mixture was refluxed for 2 h
  3. customAfter completion of the reaction
  4. customthe product was purified

출처 및 근거

ORD 기록
ord-343a84def31d43f6be2ecd17683f8e60
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04921863

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