Trifluoroacetic acid → 2(S)-(L-histidyl)amino-1-cyclohexyl-(S)-hydroxy-6-methylheptane

HRID 1649921노트

반응식

HRID 1649921 반응식
C(OC([NH:8][C@H:9]([C:16]([NH:18][C@H:19]([C@@H:27](O)[CH2:28][CH2:29][CH:30]([CH3:32])[CH3:31])[CH2:20][CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:17])[CH2:10][C:11]1[N:15]=[CH:14][NH:13][CH:12]=1)=O)(C)(C)C.FC(F)(F)C(O)=[O:37]>C(OCC)(=O)C>[NH2:8][C@H:9]([C:16]([NH:18][C@@H:19]([CH2:27][CH2:28][CH2:29][CH:30]([CH3:32])[CH3:31])[C@@H:20]([OH:37])[CH:21]1[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]1)=[O:17])[CH2:10][C:11]1[N:15]=[CH:14][NH:13][CH:12]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178444654HCID 178444654, 화합물

생성물 1

HCID 1784439352(S)-(L-histidyl)amino-1-cyclohexyl-(S)-hydroxy-6-methylheptane

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A solution of 2(S)-(N-t-butoxycarbonyl-L-histidyl)amino-1-cyclohexyl-3(S)-hydroxy-6-methylheptane (383 mg) in trifluoroacetic acid (10 ml) was stirred at 0° C. for 30 minutes. After concentration of the mixture in vacuo, the residue was dissolved in ethyl acetate (20 ml). The solution was washed with saturated sodium bicarbonate solution, dried over magnesium sulfate, and concentrated in vacuo to give 2(S)-(L-histidyl)amino-1-cyclohexyl-(S)-hydroxy-6-methylheptane (275 mg) as an amorphous powder.

후처리

  1. washThe solution was washed with saturated sodium bicarbonate solution
  2. dry with materialdried over magnesium sulfate
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-25ae1cc3e60545f3a5d2f548485cefc4
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04921855

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