4-Amino-5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylic acid → 5-Chloro-4-methoxy-2,2-dimethyl-2,3-dihydro-7-benzofurancarboxylic acid

반응식

NC1C2C[C:9](C)(C)[O:10]C=2C(C(OC)=O)=CC=1.N[C:18]1[C:23]2[CH2:24][C:25]([CH3:28])([CH3:27])[O:26][C:22]=2[C:21]([C:29]([OH:31])=[O:30])=[CH:20][C:19]=1[Cl:32]>>[Cl:32][C:19]1[CH:20]=[C:21]([C:29]([OH:31])=[O:30])[C:22]2[O:26][C:25]([CH3:28])([CH3:27])[CH2:24][C:23]=2[C:18]=1[O:10][CH3:9]

참가 물질

반응물 2

HCID 106577584-Amino-5-chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-carboxylic acid

HCID 14838335Methyl 4-amino-2,2-dimethyl-2,3-dihydro-7-benzofurancarboxylate

생성물 1

HCID 148383345-Chloro-4-methoxy-2,2-dimethyl-2,3-dihydro-7-benzofurancarboxylic acid

실험 절차

Following the same procedure, 19.9 g of methyl 4-amino-2,2-dimethyl-2,3-dihydro-7-benzofurancarboxylate was transformed into 20.1 g of 4-amino-5-chloro-2,2-dimethyl-2,3-dihydro-7-benzofurancarboxylic acid, m.p. 176°-178° C.

출처 및 근거

ORD 기록: ord-89ca90666a22428392cd7a83da234317
출처 데이터셋: uspto-grants-1990_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04921982

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