Boron trifluoride etherate → Ethyl 4-(mercaptomethyl)-2-methyl-1,3-dithiolane-2-propanoate

HRID 1650248노트

반응식

HRID 1650248 반응식
[SH:1][CH2:2][CH:3]([SH:6])[CH2:4][SH:5].[C:7]([O:14][CH2:15][CH3:16])(=[O:13])[CH2:8][CH2:9][C:10]([CH3:12])=O.B(F)(F)F.CCOCC>C(Cl)Cl>[SH:1][CH2:2][CH:3]1[CH2:4][S:5][C:10]([CH3:12])([CH2:9][CH2:8][C:7]([O:14][CH2:15][CH3:16])=[O:13])[S:6]1

참가 물질

5

반응물 3

HCID 8000Boron trifluoride etherateHCID 10883Ethyl levulinateHCID 784951,2,3-Propanetrithiol

생성물 1

HCID 14405950Ethyl 4-(mercaptomethyl)-2-methyl-1,3-dithiolane-2-propanoate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The title compound was prepared according to the procedure of Example 1 using 1,2,3-trimercaptopropane (5.6 g, 0.04 mol), ethyl levulinate (5.8 g, 0.04 mol) and boron trifluoride etherate (1.25 ml) in methylene chloride (150 ml). The crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent to give 3.35 g (31%) of product.

후처리

  1. customThe crude product was chromatographed on silica gel using 5% ethyl acetate/hexane as eluent

출처 및 근거

ORD 기록
ord-7cc069acdfad4109be4f3cc6cd629c36
출처 데이터셋
uspto-grants-1990_05
특허 번호
US04923891

반응 노트

불러오는 중…